A depressor substance in fecal extracts

Pressure range for release of renomedullary depressor substance in rabbits.

We investigated the relation between renal perfusion pressure and the release of a renal vasodepressor substance in vivo to determine whether this substance was released at physiological pressures. We perfused the left kidneys of anesthetized rabbits using an extracorporeal circuit that allowed renal perfusion pressures to be set at 65 mm Hg (control) and increased to 95, 125, 155, or 185 mm Hg...

The Nature of the Depressor Substance of the Blood.

Observations on the Depressor Extracts of Human Blood and on the Vascular Action of Extracts of Rabbit and Dog Blood

1. Alcoholic extracts of the plasma of rabbits obtained from arterial or venous blood differ from those of human plasma in having a marked depressor action on the blood pressure of anesthetized cats. This action is unantagonized on atropinization. Extracts of the plasma of dogs, on the other hand, are almost without vascular effect. 2. Ultrafiltrates of the plasma of rabbits are actively vasode...

BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS II. CHARACTERIZATION" OF TttE BACTERICIDAL SUBSTANCE IN LEUCOCYTE MITOCHONDRIAL EXTRACTS

In the preceding paper (1), it was reported that rat leucocyfic extracts prepared by ultrasonic disintegration of polymorphonuclear neutrophils (leucocytes) were bactericidal against both Gram-negative and Gram-positive organisms. The bactericidal activity of these extracts was confined primarily to the mitochondria. The purpose of this report is to characterize this bactericidal substance or s...

Further Investigation upon the Influence of Organ Extracts of Cold-blooded Animals on the Blood Pressures

1. None of the extracts examined are very potent in small doses. A noticeable effect, however, is produced upon the blood pressure by the extract of fifteen milligrams of shark testis. 2. A small dose of a five per cent. shark testis extract seems to show more pressor action than a larger dose of the same solution. 3. The fall of blood-pressure is due to a vaso-dilation. 4. After repeated (seve...